TBC1D1

Also known as TBC, TBC1, TBC1 domain family member 1

TBC1 domain family member 1 is a protein that in humans is encoded by the TBC1D1 gene.

In the Vinony graph

Within Vinony's link graph, TBC1D1 is referenced by 5 other articles, and connects out to PubMed, human chromosome 4 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 4.

Its subject is documented across 5 Wikipedia language editions.

Gene data

TBC1D1

Name: TBC1 domain family member 1
Type: protein-coding
Position: 37,890,673–38,139,175 (+)
Aliases: TBC, TBC1
Ensembl: ENSG00000065882
RefSeq RNA: NM_001253912.2, NM_001253913.2, NM_001253914.2, NM_001253915.2, NM_001396959.1
RefSeq protein: NP_001240841.1, NP_001240842.1, NP_001240843.1, NP_001240844.1, NP_001383888.1

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM, Mar 2008].

Gene Ontology

Biological process

regulation of cilium assembly

Molecular function

GTPase activator activity protein binding

Cellular component

nucleus nucleolus Golgi apparatus

Pathways

AMPK signaling pathway - Homo sapiens (human)Translocation of SLC2A4 (GLUT4) to the plasma membrane Membrane Trafficking Vesicle-mediated transport Focal Adhesion-PI3K-Akt-mTOR-signaling pathway

via MyGene.info

Gene · Ensembl

TBC1 domain family member 1

Symbol: TBC1D1
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:37,890,673-38,139,175
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 56856
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/23216
genomic end: 38140796
genomic start: 37891084
chromosome: human chromosome 4
cytogenetic location: 4p14
expressed in: ascending aorta

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

TBC1 domain family member 1 is a protein that in humans is encoded by the TBC1D1 gene.

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and cell differentiation. These proteins share significant homology with TRE2 (USP6), yeast Bub2, and CDC16 (White et al., 2000).[supplied by OMIM]

Excerpted from Wikipedia’s “TBC1D1” article, available under the CC BY-SA 4.0 licence.