TCTN3

Also known as C10orf61, JBTS18, OFD4, TECT3, tectonic family member 3

Tectonic family member 3 is a protein in humans that is encoded by the TCTN3 gene.

In the Vinony graph

Within Vinony's link graph, TCTN3 is referenced by 4 other articles, and connects out to human chromosome 10, Ensembl genome database project and protein.

It is catalogued under the topic Genes on human chromosome 10.

Its subject is documented across 6 Wikipedia language editions.

Gene data

TCTN3

Name: tectonic family member 3
Type: protein-coding
Position: 95,659,823–95,694,143 (−)
Aliases: C10orf61, JBTS18, OFD4, TECT3
Ensembl: ENSG00000119977
RefSeq RNA: NM_001143973.2, NM_001410982.1, NM_015631.6, XM_005269690.3, XM_011539627.3
RefSeq protein: NP_001137445.1, NP_001397911.1, NP_056446.4, XP_005269747.2, XP_011537929.2

This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012].

Gene Ontology

Biological process

smoothened signaling pathway smoothened signaling pathway positive regulation of apoptotic process cilium assembly cilium assembly cilium assembly protein localization to ciliary transition zone

Molecular function

protein binding

Cellular component

nucleus membrane ciliary transition zone MKS complex ciliary membrane

Pathways

Organelle biogenesis and maintenance Cilium Assembly Anchoring of the basal body to the plasma membrane Assembly of the 9+0 primary cilium Genes related to primary cilium development (based on CRISPR)Joubert Syndrome Ciliopathies

via MyGene.info

Gene · Ensembl

tectonic family member 3

Symbol: TCTN3
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:95,659,823-95,694,143
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 9221
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/26123
genomic end: 97453900
genomic start: 95659823
chromosome: human chromosome 10
cytogenetic location: 10q24.1

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Tectonic family member 3 is a protein in humans that is encoded by the TCTN3 gene.

This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Oral-facial-digital syndrome IV and Joubert syndrome 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012].

Excerpted from Wikipedia’s “TCTN3” article, available under the CC BY-SA 4.0 licence.