HomoloGene
Sign in to saveHomoloGene, a tool of the United States National Center for Biotechnology Information (NCBI), is a system for automated detection of homologs (similarity attributable to descent from a common ancestor) among the annotated genes of several completely sequenced eukaryotic genomes.
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Vinony's link graph records 12,421 inbound references to HomoloGene, and connects out to dog, Animalia and human.
It is catalogued under topics including Bioinformatics and Genetics software.
Vinony links it to 16 Wikipedia language editions.
Wikidata facts
- Instance of
- database
- Main subject
- gene
- Official website
- www.ncbi.nlm.nih.gov/homologene
Show 1 more fact
- language of work or name
- English language
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
12 sectionsContents
- Input organisms
- [[Metazoa]]
- [[Vertebrates]]
- [[Invertebrates]]
- [[Fungi]]
- [[Plants]]
- [[Dicots]]
- [[Monocots]]
- [[Protista]]
- Interface
- References
- External links
HomoloGene, a tool of the United States National Center for Biotechnology Information (NCBI), is a system for automated detection of homologs (similarity attributable to descent from a common ancestor) among the annotated genes of several completely sequenced eukaryotic genomes.
The HomoloGene processing consists of the protein analysis from the input organisms. Sequences are compared using blastp, then matched up and put into groups, using a taxonomic tree built from sequence similarity, where closer related organisms are matched up first, and then further organisms are added to the tree. The protein alignments are mapped back to their corresponding DNA sequences, and then distance metrics as molecular distances Jukes and Cantor (1969), Ka/Ks ratio can be calculated.
Excerpted from Wikipedia’s “HomoloGene” article, available under the CC BY-SA 4.0 licence.