Structure via PubChem · Public domain (PubChem)
testolattone
Sign in to saveAlso known as SQ-9538, Teslac®, (4aS,4bR,10aR,10bS,12aS)-10a,12a-dimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydro-2H-naphtho[2,1-f]chromene-2,8(4bH)-dione, 1,2-didehydrotestololactone, 1-dehydrotestololactone, Delta(1)-testololactone, 13-hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oic acid delta-lactone, D-homo-17a-oxaandrosta-1,4-diene-3,17-dione
composto chimico
Chemical data
- Formula
- C19H24O3
- Molecular weight
- 300.4 g/mol
- IUPAC name
- (4aS,4bR,10aR,10bS,12aS)-10a,12a-dimethyl-4,4a,4b,5,6,10b,11,12-octahydro-3H-naphtho[2,1-f]chromene-2,8-dione
- SMILES
- C[C@]12CC[C@H]3[C@H]([C@@H]1CCC(=O)O2)CCC4=CC(=O)C=C[C@]34C
- InChIKey
- BPEWUONYVDABNZ-DZBHQSCQSA-N
- XLogP
- 3
- Polar surface area
- 43.4 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1969
- Admin. routes
- oral, parenteral
- Indications
- precocious puberty
via ChEMBL · EBI
Research
230 papers- Anti-estrogens and aromatase inhibitors: tamoxifen and testolactone.Journal of endocrinological investigation · 1988
- [Testotoxicosis].Nihon rinsho. Japanese journal of clinical medicine · 2006
- Comprehensive Zebrafish Water Tank Experiment for Metabolic Studies of Testolactone.Zebrafish · 2020
- Testolactone-associated high androgen levels, a pharmacologic effect or a laboratory artifact?The Journal of clinical endocrinology and metabolism · 1998
- Single-cell enzymatic cascade synthesis of testolactone enabled by engineering of polycyclic ketone monooxygenase and multi-gene expression fine-tuning.International journal of biological macromolecules · 2024
via PubMed
Wikidata facts
- Subclass of
- steroid
- Mass
- 300.172545
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₉H₂₄O₃
- medical condition treated
- breast cancer
- canonical SMILES
- CC12CCC3C(C1CCC(=O)O2)CCC4=CC(=O)C=CC34C
- isomeric SMILES
- C[C@]12CC[C@H]3[C@H]([C@@H]1CCC(=O)O2)CCC4=CC(=O)C=C[C@]34C
- physically interacts with
- cytochrome P450 family 19 subfamily A member 1
- Commons category
- Testolactone
via Wikidata · CC0
Article · Italiano
Il Testolattone (17α-Oxa-D-omoandrosta-1,4-diene-3,17-dione) è un agente antineoplastico derivato del progesterone ed è utilizzato per trattare gli stadi avanzati del cancro al seno. È un antineoplastico sintetico strutturalmente distinto dagli androgeni steroidei poiché possiede un anello lattonico 6 atomi al posto del classico anello carbociclico a 5 atomi.
Abstract from DBpedia / Wikipedia · CC BY-SA
Available in 7 languages
via Wikidata sitelinks · CC0