THO complex subunit 5 homolog is a protein that in humans is encoded by the THOC5 gene. THOCs is a member of THO complex which is a subcomplex of the transcription/export complex (TREX).
THO complex subunit 5 homolog is a protein that in humans is encoded by the THOC5 gene. THOCs is a member of THO complex which is a subcomplex of the transcription/export complex (TREX).
THOC5 is evolutionarily conserved in higher eukaryotes, however the exact roles of THOC5 in transcription and mRNA export are still unclear. THOC5 is phosphorylated by several protein kinases at multiple residues upon extracellular stimuli. These include stimulation with growth factors/cytokines/chemokines, or DNA damage reagents. Furthermore, THOC5 is a substrate for several oncogenic tyrosine kinases, suggesting that THOC5 may be involved in cancer development.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).