TNFRSF9
Sign in to saveAlso known as 4-1BB, CD137, CDw137, ILA, tumor necrosis factor receptor superfamily member 9, TNF receptor superfamily member 9
CD137, a member of the tumor necrosis factor (TNF) receptor family, is a type 1 transmembrane protein, expressed on surfaces of leukocytes and non-immune cells. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB, and induced by lymphocyte activation (ILA). It is of interest to immunologists as a co-stimulatory immune checkpoint molecule, and as a potential target in cancer immunotherapy.
Gene data
TNFRSF9- Name
- TNF receptor superfamily member 9
- Type
- protein-coding
- Position
- 7,915,871–7,943,165 (−)
- Aliases
- 4-1BB, CD137, CDw137, ILA, IMD109
- Ensembl
- ENSG00000049249
- RefSeq RNA
- NM_001561.6, XM_006710618.4, XM_047419672.1, XM_054336415.1, XM_054336416.1
- RefSeq protein
- NP_001552.2, XP_006710681.1, XP_047275628.1, XP_054192390.1, XP_054192391.1
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
TNF receptor superfamily member 9
- Symbol
- TNFRSF9
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:7,915,871-7,943,165
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 1199
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3604
- genomic end
- 8000926
- genomic start
- 7915871
- chromosome
- human chromosome 1
- cytogenetic location
- 1p36.23
- expressed in
- gallbladder
via Wikidata · CC0
~6 min read
Encyclopedic overview
13 sectionsContents
- Expression
- Regulation of the immune system
- Atherosclerosis
- Inflammation
- Endothelial cells
- Interactions
- As a drug target
- Cancer immunotherapy
- Utomilumab
- See also
- References
- External links
- Further reading
CD137, a member of the tumor necrosis factor (TNF) receptor family, is a type 1 transmembrane protein, expressed on surfaces of leukocytes and non-immune cells. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB, and induced by lymphocyte activation (ILA). It is of interest to immunologists as a co-stimulatory immune checkpoint molecule, and as a potential target in cancer immunotherapy.
==Expression==
Excerpted from Wikipedia’s “TNFRSF9” article, available under the CC BY-SA 4.0 licence.