LAG3
Sign in to saveAlso known as CD223, lymphocyte activating 3
protein-coding gene in the species Homo sapiens
Gene data
LAG3- Name
- lymphocyte activating 3
- Type
- protein-coding
- Position
- 6,772,360–6,778,455 (+)
- Aliases
- CD223
- Ensembl
- ENSG00000089692
- RefSeq RNA
- NM_001414176.1, NM_001414177.1, NM_002286.6
- RefSeq protein
- NP_001401105.1, NP_001401106.1, NP_002277.4
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
plasmacytoid dendritic cell activationplasmacytoid dendritic cell activationnegative regulation of T cell mediated immune response to tumor cellnegative regulation of T cell mediated immune response to tumor cellcell surface receptor signaling pathwaynegative regulation of regulatory T cell differentiationnegative regulation of regulatory T cell differentiationregulation of immune response
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
lymphocyte activating 3
- Symbol
- LAG3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:6,772,360-6,778,455
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI