TOP2A

Also known as TOP2, TP2A, topoisomerase (DNA) II alpha, DNA topoisomerase II alpha, TOPIIA, TOP2alpha

DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene.

Gene data

TOP2A

Name: DNA topoisomerase II alpha
Type: protein-coding
Position: 40,388,525–40,417,896 (−)
Aliases: TOP2, TOP2alpha, TOPIIA, TP2A
Ensembl: ENSG00000131747
RefSeq RNA: NM_001067.4, XM_005257632.2, XM_011525165.3, XM_054317034.1, XM_054317035.1
RefSeq protein: NP_001058.2, XP_005257689.1, XP_011523467.1, XP_054173009.1, XP_054173010.1

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].

Pathways

Transcription of E2F targets under negative control by DREAM complex G0 and Early G1 Cell Cycle SUMOylation SUMOylation SUMO E3 ligases SUMOylate target proteins SUMO E3 ligases SUMOylate target proteins Metabolism of proteins Metabolism of proteins Mitotic G1 phase and G1/S transition

via MyGene.info

Wikidata facts

Image: 1zxn.jpg

Show 5 more facts

HomoloGene ID: 830
exact match: identifiers.org/ncbigene/7153
genomic end: 40417896
genomic start: 40388525
cytogenetic location: 17q21.2

Sources (4)

via Wikidata · CC0

~1 min read

Article

5 sections

Contents

Interactions
In other species
See also
References
Further reading

DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene.

Topoisomerase IIα relieves topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several chemotherapy agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.