SUMO1
Sign in to saveAlso known as DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3
Small ubiquitin-related modifier 1 is a protein that in humans is encoded by the SUMO1 gene.
Gene data
SUMO1- Name
- small ubiquitin like modifier 1
- Type
- protein-coding
- Position
- 202,206,171–202,238,604 (−)
- Aliases
- DAP1, GMP1, OFC10, PIC1, SMT3, SMT3C, SMT3H3, UBL1
- Ensembl
- ENSG00000116030
- RefSeq RNA
- NM_001005781.2, NM_001005782.2, NM_001371392.1, NM_001371393.1, NM_001371394.1
- RefSeq protein
- NP_001005781.1, NP_001005782.1, NP_001358321.1, NP_001358322.1, NP_001358323.1
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
small ubiquitin like modifier 1
- Symbol
- SUMO1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:202,206,171-202,238,604
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SUMO1 PDB 1a5r.png
Show 8 more facts
- HomoloGene ID
- 2514
- genomic start
- 203070903
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7341
- genomic end
- 203103331
- chromosome
- human chromosome 2
- Commons category
- Small ubiquitin-related modifier proteins
- cytogenetic location
- 2q33.1
Sources (4)
via Wikidata · CC0
~3 min read
Encyclopedic overview
8 sectionsContents
- Function
- Interactions
- Role in the heart
- As a drug target
- See also
- References
- Further reading
- External links
Small ubiquitin-related modifier 1 is a protein that in humans is encoded by the SUMO1 gene.
== Function ==
Excerpted from Wikipedia’s “SUMO1” article, available under the CC BY-SA 4.0 licence.