anthracycline antibiotic
Also known as anthracyclines, anthracycline antibiotics
thumb|Doxorubicin as an intercalating agent. Two doxorubicin molecules intercalated within DNA.
Article
15 sectionsContents
- History
- Clinical trials
- Mechanism of action
- DNA Intercalation
- Topoisomerase II poison
- Reactive oxygen species
- DNA adduct formation
- Clinical implications
- Side effects
- Liposomal-based clinical formulations
- Adverse drug interactions
- See also
- References
- Notes
- External links
thumb|Doxorubicin as an intercalating agent. Two doxorubicin molecules intercalated within DNA.
Anthracyclines are a class of drugs used in cancer chemotherapy that are extracted from Streptomyces peucetius bacterium. These compounds are used to treat many cancers, including leukemias, lymphomas, breast, stomach, uterine, ovarian, bladder cancer, and lung cancers. The first anthracycline discovered was daunorubicin (trade name Daunomycin), which is produced naturally by Streptomyces peucetius, a species of Actinomycetota. Clinically the most important anthracyclines are doxorubicin, daunorubicin, epirubicin and idarubicin.