TPP1

Name

tripeptidyl peptidase 1

Type

protein-coding

Position

6,612,768–6,619,448 (−)

Aliases

CLN2, GIG1, LPIC, SCAR7, TPP-1

Ensembl

ENSG00000166340

RefSeq RNA

NM_000391.4

RefSeq protein

NP_000382.3

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

tripeptidyl peptidase 1

Symbol

TPP1

Biotype

Protein coding

Organism

Homo sapiens

Location

11:6,612,768-6,619,448

Strand

Reverse (−)

Assembly

GRCh38