TRIB3
Sign in to saveAlso known as C20orf97, NIPK, SINK, SKIP3, TRB3, tribbles pseudokinase 3
Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.
Gene data
TRIB3- Name
- tribbles pseudokinase 3
- Type
- protein-coding
- Aliases
- C20orf97, NIPK, SINK, SKIP3, TRB3
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014].
via MyGene.info
Wikidata facts
Show 5 more facts
- exact match
- identifiers.org/ncbigene/57761
- HomoloGene ID
- 10902
- genomic end
- 378203
- genomic start
- 361261
- cytogenetic location
- 20p13
Sources (4)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.
== Function ==
Connections
Q180686
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human chromosome 20
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Ensembl genome database project
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protein-serine-threonine kinases
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RPS6KB1
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protein
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enzyme
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Wikidata
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gene
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chromosome
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digital object identifier
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apoptotic process
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bibcode
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human genome
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Q229883
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base pair
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locus
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gene expression
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Online Mendelian Inheritance in Man
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