TRIB3
Sign in to saveAlso known as C20orf97, NIPK, SINK, SKIP3, TRB3, tribbles pseudokinase 3
Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.
Gene data
TRIB3- Name
- tribbles pseudokinase 3
- Type
- protein-coding
- Position
- 362,835–398,964 (+)
- Aliases
- C20orf97, NIPK, SINK, SKIP3, TRB3
- Ensembl
- ENSG00000101255
- RefSeq RNA
- NM_001301188.1, NM_001301190.1, NM_001301193.1, NM_001301196.1, NM_001301201.1
- RefSeq protein
- NP_001288117.1, NP_001288119.1, NP_001288122.1, NP_001288125.1, NP_001288130.1
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
tribbles pseudokinase 3
- Symbol
- TRIB3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:362,835-398,964
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- exact match
- identifiers.org/ncbigene/57761
- HomoloGene ID
- 10902
- found in taxon
- Homo sapiens
- genomic end
- 378203
- genomic start
- 361261
- chromosome
- human chromosome 20
- cytogenetic location
- 20p13
- expressed in
- anterior pituitary
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.
== Function ==
Excerpted from Wikipedia’s “TRIB3” article, available under the CC BY-SA 4.0 licence.