trogocytosis
Sign in to savethumb|Volumetric reconstruction from confocal slices of a Ramos-RAW cell interface. Rituximab|RTX-Al488-coated (green), PKH26-labelled Ramos cells (red) were incubated with RAW cells for 45 minutes at 37°C. RAW cells were labelled with anti-CD11b-APC (cyan). The RAW cell has extensively trogocytosed both RTX and PKH26. Inset shows the dotted area above it without the PKH26 channel overlaid, revealing the concentration of RTX-Al488 at the cell-cell interface, otherwise depleted from the rest of the Ramos cell. Trogocytosis reaction was halted by fixation 45 min after co-incubation. Ramos cells
Research
517 papers- Trogocytosis in Unicellular Eukaryotes.Cells · 2021
- Trogocytosis and cross-dressing in antigen presentation.Current opinion in immunology · 2023
- Trogocytosis-mediated immune evasion in the tumor microenvironment.Experimental & molecular medicine · 2025
- Trogocytosis in CAR immune cell therapy: a key mechanism of tumor immune escape.Cell communication and signaling : CCS · 2024
- Lymphocytes and Trogocytosis-Mediated Signaling.Cells · 2021
via PubMed
~9 min read
Encyclopedic overview
9 sectionsContents
- Discovery
- Cell types
- Mechanism of action
- Physiological consequences
- Applications
- In serotherapy
- As immunomonitoring tools
- See also
- References
thumb|Volumetric reconstruction from confocal slices of a Ramos-RAW cell interface. Rituximab|RTX-Al488-coated (green), PKH26-labelled Ramos cells (red) were incubated with RAW cells for 45 minutes at 37°C. RAW cells were labelled with anti-CD11b-APC (cyan). The RAW cell has extensively trogocytosed both RTX and PKH26. Inset shows the dotted area above it without the PKH26 channel overlaid, revealing the concentration of RTX-Al488 at the cell-cell interface, otherwise depleted from the rest of the Ramos cell. Trogocytosis reaction was halted by fixation 45 min after co-incubation. Ramos cells are approximately 12 μm in diameter.
Trogocytosis (; gnaw) is when a cell nibbles another cell. It is a process whereby lymphocytes (B, T and NK cells) conjugated to antigen-presenting cells extract surface molecules from these cells and express them on their own surface. The molecular reorganization occurring at the interface between the lymphocyte and the antigen-presenting cell during conjugation is also called "immunological synapse".
Excerpted from Wikipedia’s “trogocytosis” article, available under the CC BY-SA 4.0 licence.