TCL1A
Sign in to saveAlso known as TCL1, T-cell leukemia/lymphoma 1A, T cell leukemia/lymphoma 1A, TCL1 family AKT coactivator A
T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.
Gene data
TCL1A- Name
- TCL1 family AKT coactivator A
- Type
- protein-coding
- Aliases
- TCL1
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010].
via MyGene.info
Wikidata facts
- Image
- Protein TCL1A PDB 1jsg.png
Show 5 more facts
- HomoloGene ID
- 7565
- exact match
- identifiers.org/ncbigene/8115
- genomic end
- 96180533
- genomic start
- 95709947
- cytogenetic location
- 14q32.13
Sources (4)
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- Interactions
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T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.
== Interactions ==