lymphotoxin-alpha
Sign in to savethumb | right | Structure of the LTA protein. Based on PyMOL rendering of PDB 1tnr. Lymphotoxin is a member of the tumor necrosis factor (TNF) superfamily of cytokines, whose members are responsible for regulating the growth and function of lymphocytes and are expressed by a wide variety of cells in the body.
Key facts
- Protein.Name
- lymphotoxin alpha (TNF superfamily, member 1)
- Protein.HGNCid
- 6709
- Protein.Symbol
- LTA
- Protein.AltSymbols
- TNFB
- Protein.EntrezGene
- 4049
- Protein.OMIM
- 153440
- Protein.RefSeq
- NM_000595
- Protein.UniProt
- P01374
- Protein.Chromosome
- 6
- Protein.Arm
- p
- Protein.Band
- 21.3
via Wikipedia infobox
Research
3,968 papers- The role of lymphotoxin-α in rheumatoid arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018
- Lymphotoxin-alpha contributes to lymphangiogenesis.Blood · 2010
- Tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta).Current opinion in immunology · 1992
- Lymphotoxin α revisited: general features and implications in rheumatoid arthritis.Arthritis research & therapy · 2011
- Lymphotoxin.Annual review of immunology · 1988
via PubMed
Article
7 sectionsContents
- Structure and function
- Receptor binding and signaling activation
- Carcinogenic interactions
- See also
- References
- Further reading
- External links
thumb | right | Structure of the LTA protein. Based on PyMOL rendering of PDB 1tnr. Lymphotoxin is a member of the tumor necrosis factor (TNF) superfamily of cytokines, whose members are responsible for regulating the growth and function of lymphocytes and are expressed by a wide variety of cells in the body.
Lymphotoxin plays a critical role in developing and preserving the framework of lymphoid organs and of gastrointestinal immune responses, as well as in the activation signaling of both the innate and adaptive immune responses. Lymphotoxin alpha (LT-α, previously known as TNF-beta) and lymphotoxin beta (LT-β), the two forms of lymphotoxin, each have distinctive structural characteristics and perform specific functions.