ULK1

Also known as ATG1, ATG1A, UNC51, Unc51.1, hATG1, unc-51 like autophagy activating kinase 1

Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene.

Gene data

ULK1

Name: unc-51 like autophagy activating kinase 1
Type: protein-coding
Position: 131,894,596–131,923,161 (+)
Aliases: ATG1, ATG1A, UNC51, Unc51.1, hATG1
Ensembl: ENSG00000177169
RefSeq RNA: NM_003565.4, XM_011538798.4, XM_011538799.3, XM_054373404.1, XM_054373405.1
RefSeq protein: NP_003556.2, XP_011537100.1, XP_011537101.1, XP_054229379.1, XP_054229380.1

Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including autophagosome assembly; positive regulation by symbiont of host autophagy; and protein phosphorylation. Located in autophagosome; cytosol; and phagophore assembly site membrane. Is extrinsic component of autophagosome membrane; extrinsic component of omegasome membrane; and extrinsic component of phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Apr 2022]

Pathways

Mitophagy - animal - Homo sapiens (human)Autophagy - animal - Homo sapiens (human)mTOR signaling pathway - Homo sapiens (human)AMPK signaling pathway - Homo sapiens (human)Longevity regulating pathway - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)Amyotrophic lateral sclerosis - Homo sapiens (human)Huntington disease - Homo sapiens (human)Spinocerebellar ataxia - Homo sapiens (human)Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

unc-51 like autophagy activating kinase 1

Symbol: ULK1
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:131,894,596-131,923,161
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 2640
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/8408
genomic end: 131923150
genomic start: 131894622
chromosome: human chromosome 12
cytogenetic location: 12q24.33
expressed in: nucleus accumbens

Sources (6)

via Wikidata · CC0

~5 min read

Encyclopedic overview

7 sections

Contents

Function
Interactions
Structure
Post-translational modifications
Related diseases
References
Further reading

Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene.

Unc-51-like autophagy-activating kinases 1 and 2 (ULK1/2) are two similar isoforms of an enzyme that in humans is encoded by the ULK1/2 genes. The enzyme is specifically a kinase that is involved with autophagy, particularly in response to amino acid withdrawal. Not many studies have been done comparing the two isoforms, but some differences have been recorded.

Excerpted from Wikipedia’s “ULK1” article, available under the CC BY-SA 4.0 licence.