uroplakin 1A
Sign in to saveAlso known as tspan-21, uroplakin Ia, UPIa, UPKa, tetraspanin-21, UPK1A, uroplakin-1a
Uroplakin-1a (UP1a) is a protein that in humans is encoded by the UPK1A gene.
Protein · UniProt
Uroplakin-1a
- Gene
- UPK1A
- Organism
- Homo sapiens (Human)
- Length
- 258 aa
- Molecular mass
- 28,879 Da
- Evidence
- 1: Evidence at protein level
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)
Swiss-Prot (reviewed) · via UniProt
Research
115 papers- Uroplakin 1a Interacts with Regucalcin and Proteasome Subunit Beta 1.Reproductive sciences (Thousand Oaks, Calif.) · 2023
- Uroplakin 1a Knockout Mice Display Marginal Reduction in Fecundity, Decreased Bacterial Clearance Capacity, and Drastic Changes in the Testicular Transcriptome.Reproductive sciences (Thousand Oaks, Calif.) · 2023
- Large-scale human tissue analysis identifies Uroplakin 1a as a putative diagnostic marker for urothelial cancer.Pathology, research and practice · 2022
- Long Noncoding RNA Expression Profiling Reveals Upregulation of Uroplakin 1A and Uroplakin 1A Antisense RNA 1 under Hypoxic Conditions in Lung Cancer Cells.Molecules and cells · 2020
- Reciprocal regulation of HIF-1α and Uroplakin 1A promotes glycolysis and proliferation in Hepatocellular Carcinoma.Journal of Cancer · 2020
via PubMed
Wikidata facts
- Instance of
- protein
Show 2 more facts
- molecular function
- protein binding
- found in taxon
- Homo sapiens
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Uroplakin-1a (UP1a) is a protein that in humans is encoded by the UPK1A gene.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.
Excerpted from Wikipedia’s “uroplakin 1A” article, available under the CC BY-SA 4.0 licence.