WNT10B

Also known as SHFM6, WNT-12, Wnt family member 10B, STHAG8

Protein Wnt-10b (formerly Wnt12) is a protein that in humans is encoded by the WNT10B gene.

Gene data

WNT10B

Name: Wnt family member 10B
Type: protein-coding
Position: 48,965,340–48,971,735 (−)
Aliases: SHFM6, STHAG8, WNT-12
Ensembl: ENSG00000169884
RefSeq RNA: NM_003394.4
RefSeq protein: NP_003385.2

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

chondrocyte differentiation Wnt signaling pathway neuron differentiation neuron differentiation positive regulation of apoptotic process cell fate commitment negative regulation of fat cell differentiation animal organ development

Molecular function

signaling receptor binding frizzled binding cytokine activity protein binding receptor ligand activity

Cellular component

extracellular region extracellular region extracellular region extracellular region

Pathways

mTOR signaling pathway - Homo sapiens (human)Wnt signaling pathway - Homo sapiens (human)Hippo signaling pathway - Homo sapiens (human)Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)Melanogenesis - Homo sapiens (human)Cushing syndrome - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)Human papillomavirus infection - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)

via MyGene.info

Wikidata facts

Show 5 more facts

exact match: identifiers.org/ncbigene/7480
HomoloGene ID: 20721
genomic end: 48971735
genomic start: 49359123
cytogenetic location: 12q13.12

Sources (5)

via Wikidata · CC0

~1 min read

Article

2 sections

Contents

References
Further reading

Protein Wnt-10b (formerly Wnt12) is a protein that in humans is encoded by the WNT10B gene.

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.