ZEB2
Sign in to saveAlso known as HSPC082, SIP-1, SIP1, SMADIP1, ZFHX1B, zinc finger E-box binding homeobox 2
Zinc finger E-box-binding homeobox 2 is a protein that in humans is encoded by the ZEB2 gene. The ZEB2 protein is a transcription factor that plays a role in the transforming growth factor β (TGFβ) signaling pathways that are essential during early fetal development.
Gene data
ZEB2- Name
- zinc finger E-box binding homeobox 2
- Type
- protein-coding
- Aliases
- HSPC082, SIP-1, SIP1, SMADIP1, ZFHX1B
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010].
via MyGene.info
Gene · Ensembl
zinc finger E-box binding homeobox 2
- Symbol
- ZEB2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:144,364,364-144,521,057
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ZEB2 PDB 2da7.png
Show 9 more facts
- HomoloGene ID
- 8868
- genetic association
- Mowat-Wilson syndrome
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9839
- genomic start
- 144364364
- chromosome
- human chromosome 2
- genomic end
- 144521057
- cytogenetic location
- 2q22.3
- expressed in
- amygdala
Sources (7)
via Wikidata · CC0
~3 min read
Encyclopedic overview
5 sectionsContents
- Function
- Clinical significance
- References
- Further reading
- External links
Zinc finger E-box-binding homeobox 2 is a protein that in humans is encoded by the ZEB2 gene. The ZEB2 protein is a transcription factor that plays a role in the transforming growth factor β (TGFβ) signaling pathways that are essential during early fetal development.
== Function ==
Excerpted from Wikipedia’s “ZEB2” article, available under the CC BY-SA 4.0 licence.