Thioethers

Epitizide is a diuretic. It is often combined with triamterene.

Tiadenol is a hypolipidemic agent.

2C-T-13, also known as 4-(2-methoxyethylthio)-2,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and 2C families.

chemical compound

Tedatioxetine (developmental code name Lu AA24530) is an experimental antidepressant developed by H. Lundbeck A/S for the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD). It acts as a triple reuptake inhibitor (TRI) with preference for serotonin and norepinephrine over dopamine, and as an antagonist at 5-HT2A, 5-HT2C, 5-HT3, and α1A-adrenergic receptors. In 2007 Lundbeck and Takeda entered into a partnership that included tedatioxetine but was focused on another, more advanced Lundbeck drug candidate, vortioxetine.

2C-T-8, also known as 4-cyclopropylmethylthio-2,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and 2C families.

Nolatrexed is a thymidylate synthase inhibitor.

2C-T-17, also known as '4-sec-butylthio-2,5-dimethoxyphenethylamine or as Nimitz', is a psychedelic drug of the phenethylamine and 2C families. It is taken orally.

Azalanstat (INN, codenamed RS-21607) is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor.

Terbufos is a chemical compound used in insecticides and nematicides. It is part of the chemical family of organophosphates. It is a clear, colourless to pale yellow or reddish-brown liquid and sold commercially as granulate.

2C-T-15, also known as 4-cyclopropylthio-2,5-dimethoxyphenethylamine or as Sesqui, is a psychoactive drug of the phenethylamine and 2C families.

Dimaprit is a histamine analog working as a selective H2 histamine receptor agonist.

chemical compound

Vedaclidine (INN, codenamed LY-297,802, NNC 11-1053) is an experimental analgesic drug which acts as a mixed agonist–antagonist at muscarinic acetylcholine receptors, being a potent and selective agonist for the M1 and M4 subtypes, yet an antagonist at the M2, M3 and M5 subtypes. It is orally active and an effective analgesic over 3× the potency of morphine, with side effects such as salivation and tremor only occurring at many times the effective analgesic dose. Human trials showed little potential for development of dependence or abuse, and research is continuing into possible clinical appli

Letosteine is a mucolytic patented (U.S. patent 6987120) by Piero del Soldato of Milan, Italy. He filed his application in 2000.

Lupitidine (INN; lupitidine hydrochloride (USAN); development code SKF-93479) is a long-acting H2 receptor antagonist developed by Smith, Kline & French and described as an antiulcerogenic that was never marketed. It was shown to inhibit nocturnal gastric acid secretion and, in experiments on rodents, produced diffuse neuroendocrine cell hyperplasia and an increase in multifocal glandular hyperplasia due to hypergastrinemia resulting from the pharmacological suppression of gastric acid secretion.

Oxmetidine (development code SKF 92994) is an H2 histamine receptor receptor antagonist.

Tozasertib (VX-680) is an aurora inhibitor.

Cresomycin is an experimental antibiotic. It binds to the bacterial ribosome in both Gram-negative and Gram-positive bacteria, and it has been found to be effective against multi-drug-resistant stains of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. It belongs to the bridged macrobicyclic oxepanoprolinamide antibiotics, which have similarities with lincosamides antibiotics.

Fenticlor (also spelled fentichlor) is an antibacterial and antifungal agent for topical use. It is an antimicrobial agent. It is also used in veterinary medicine. __TOC__ ==Synthesis== It is prepared by the AlCl3-catalyzed reaction of 4-chlorophenol with sulfur dichloride. It can also be prepared by chlorination of bis[2-hydroxyphenyl]sulfide.

Tiflorex (TFX), formerly known as flutiorex, is a stimulant amphetamine that was under development as an appetite suppressant in the 1970s, but appears to have been abandoned. It is structurally related to fenfluramine and 4-MTA.

Cinanserin (; developmental code name SQ-10643) is a serotonin 5-HT2A and 5-HT2C receptor antagonist which was discovered in the 1960s and was never marketed. It has about 50-fold higher affinity for the 5-HT2A receptor than for 5-HT2C, and very low affinity for 5-HT1 receptors. The drug also inhibits the 3C-like protease of SARS-CoV-1 and SARS-CoV-2, but with much lower affinity.

Hawkinsin (also known as 2-cystenyl-1,4-dihydroxycyclohexenylacetate) is an amino acid, which is formed after detoxification of a reactive tyrosine metabolite (quinol acetate) by glutathione. Hawkinsin is ninhydrin positive (a common test to detect amino acids and proteins with a free -NH2 group).

Chlorbisan is a toxic halogenated organosulfide. It is used as a microbicide.

SIB-1553A is a nicotinic acetylcholine receptor agonist that is selective for receptors with a β4 subunit. Administration of SIB-1553A improved memory and attention in a Parkinson's disease model.

chemical compound