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lupitidine
Sign in to saveLupitidine (INN; lupitidine hydrochloride (USAN); development code SKF-93479) is a long-acting H2 receptor antagonist developed by Smith, Kline & French and described as an antiulcerogenic that was never marketed. It was shown to inhibit nocturnal gastric acid secretion and, in experiments on rodents, produced diffuse neuroendocrine cell hyperplasia and an increase in multifocal glandular hyperplasia due to hypergastrinemia resulting from the pharmacological suppression of gastric acid secretion.
Chemical data
- Formula
- C21H27N5O2S
- Molecular weight
- 413.5 g/mol
- IUPAC name
- 2-[2-[[5-(2-aminopropan-2-yl)furan-2-yl]methylsulfanyl]ethylamino]-5-[(6-methyl-3-pyridinyl)methyl]-1H-pyrimidin-6-one
- SMILES
- CC1=NC=C(C=C1)CC2=CN=C(NC2=O)NCCSCC3=CC=C(O3)C(C)(C)N
- InChIKey
- CZTPLYMKHNEVHO-UHFFFAOYSA-N
- XLogP
- 1.1
- Polar surface area
- 131 Ų
- H-bond donors
- 3
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 413.18854610400007
Show 3 more facts
- canonical SMILES
- Cc1ccc(cn1)Cc2c[nH]c(nc2=O)NCCSCc3ccc(o3)C(C)(C)N
- chemical formula
- C₂₁H₂₇N₅O₂S
- Commons category
- Lupitidine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Lupitidine (INN; lupitidine hydrochloride (USAN); development code SKF-93479) is a long-acting H2 receptor antagonist developed by Smith, Kline & French and described as an antiulcerogenic that was never marketed. It was shown to inhibit nocturnal gastric acid secretion and, in experiments on rodents, produced diffuse neuroendocrine cell hyperplasia and an increase in multifocal glandular hyperplasia due to hypergastrinemia resulting from the pharmacological suppression of gastric acid secretion.
== References ==
Excerpted from Wikipedia’s “lupitidine” article, available under the CC BY-SA 4.0 licence.