4-butylresorcinol

4-Butylresorcinol, sometimes called '4-n-butylresorcinol', is a chemical used to treat hyperpigmentation of the epidermis. Hyperpigmentation is believed to be related to the enzyme tyrosinase which produces melanin. Among several chemicals known to inhibit tyrosinase production, such as hydroquinone, arbutin, and kojic acid, 4-butylresorcinol has been found to be the most powerful inhibitor by IC50, but the mode of inhibition is reversible. 4-Butylresorcinol can be used in the synthesis of tetrahydrocannabutol.

{| class="wikitable" |+Tyrosinase inhibition assay in μmol/L !compound !in vitro IC50 !in vivo |- |arbutin |> 5000 | |- |hydroquinone |> 1000 |< 40 |- |kojic acid |500 | |- |4-n-butylresorcinol |21 |13.5 |}