ACE inhibitor
Sign in to saveAlso known as Angiotensin converting enzyme inhibitor, ACE inhibitors, Angiotensin-converting enzyme inhibitor, Angiotensin-converting enzyme inhibitors, Acei, Angiotensin converting enzyme inhibitors
pharmaceutical drug used primarily for the treatment of hypertension (elevated blood pressure) and congestive heart failure
Key facts
- Use
- Hypertension
- Atc code
- C09A
- Biological target
- Angiotensin-converting enzyme
- Drugs com
- Drug Classes
- Consumer reports
- Best Buy Drugs
- Webmd
- MedicineNet RxList
- Mesh
- D000806
via Wikipedia infobox
Research
63,971 papers- ACE-inhibitor-related angioedema.Ear, nose, & throat journal · 2015
- ACE inhibitor-induced cough.DICP : the annals of pharmacotherapy · 1990
- [ACE-inhibitor induced angioedema].Laryngo- rhino- otologie · 2007
- ACE inhibitor induced intestinal angioedema.ANZ journal of surgery · 2022
- ACE inhibitor-induced cough and bronchospasm. Incidence, mechanisms and management.Drug safety · 1996
via PubMed
~25 min read
Encyclopedic overview
Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of high blood pressure and heart failure. This class of medicine works by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.
ACE inhibitors inhibit the activity of angiotensin-converting enzyme, an important component of the renin–angiotensin system which converts angiotensin I to angiotensin II, and hydrolyses bradykinin. Therefore, ACE inhibitors decrease the formation of angiotensin II, a vasoconstrictor, and increase the level of bradykinin, a peptide vasodilator. This combination is synergistic in lowering blood pressure.
Excerpted from Wikipedia’s “ACE inhibitor” article, available under the CC BY-SA 4.0 licence.