angioedema

Also known as Angioneurotic oedema, Quincke's edema, angioneurotic edema, giant urticaria, Giant Urticarias, Quincke Edema, Angioedemas, Urticarias, Giant

Key facts

Medical condition (new).name: Angioedema
Medical condition (new).synonyms: Angioedema, Quincke's edema, angioneurotic edema
Medical condition (new).image: Angioedema2010.JPG
Medical condition (new).caption: Allergic angioedema: this child is unable to open his eyes due to the swelling.
Medical condition (new).field: Allergy and immunology, emergency medicine
Medical condition (new).symptoms: Area of swelling
Medical condition (new).onset: Minutes to hours
Medical condition (new).types: Histamine mediated, bradykinin mediated
Medical condition (new).risks: Family history
Medical condition (new).diagnosis: Based on symptoms
Medical condition (new).differential: Anaphylaxis, abscess, contact dermatitis
Medical condition (new).treatment: Intubation, cricothyroidotomy
Medical condition (new).medication: Histamine: antihistamines, corticosteroids, epinephrineBradykinin: C1 esterase inhibitor, ecallantide, icatibant, fresh frozen plasma
Medical condition (new).frequency: ~100,000 per year (US)

via Wikipedia infobox

Research

11,760 papers

Angioedema without urticaria: Diagnosis and management.Allergy and asthma proceedings · 2025
Isolated angioedema: A review of classification and update on management.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
Hereditary Angioedema: A Review.WMJ : official publication of the State Medical Society of Wisconsin · 2022
Hereditary Angioedema.Immunology and allergy clinics of North America · 2023
[Angioedema].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2007

via PubMed

Wikidata facts

Image: Angioedema2010.JPG

Show 4 more facts

NCI Thesaurus ID: C112175
Commons category: Angioedema
exact match: purl.obolibrary.org/obo/HP_0100665
ICD-9-CM: 995.1

Sources (8)

via Wikidata · CC0

~14 min read

Article

16 sections

Contents

Signs and symptoms
Pathophysiology
Diagnosis
Acquired angioedema
Hereditary angioedema
Management
Allergic
Drug induced
Hereditary
Acquired, HAE types I and II, and nonhistaminergic
Prophylaxis for HAE
Epidemiology
History
See also
References
External links

Angioedema is an area of swelling (edema) of the lower layer of skin and tissue just under the skin or mucous membranes. The swelling may occur in the face, tongue, larynx, abdomen, or arms and legs. Often it is associated with hives, which are swelling within the upper skin. Onset is typically over minutes to hours.

The underlying mechanism typically involves histamine or bradykinin. The version related to histamine is due to an allergic reaction to agents such as insect bites, foods, or medications. The version related to bradykinin may occur due to an inherited problem known as C1 esterase inhibitor deficiency, medications known as angiotensin-converting enzyme inhibitors, or a lymphoproliferative disorder.