Acediasulfone (INN) is an antimicrobial drug, which also has antimalarial activity. It is a long-acting prodrug of dapsone, which is used for treating leprosy. == Synthesis == Dapsone is somewhat inconvenient to administer to patients because of its rather low water solubility. thumb|center|700px|Acediasulfone synthesis: and (1949, 1952, to Cilag Ltd.); Rawlins, (1952 to [[Parke-Davis).]] In the search for more easily administered drugs, dapsone (1) was reacted with bromoacetic acid to give acediasulfone (2) which can be administered as a water-soluble salt.
Acediasulfone (INN) is an antimicrobial drug, which also has antimalarial activity. It is a long-acting prodrug of dapsone, which is used for treating leprosy. == Synthesis == Dapsone is somewhat inconvenient to administer to patients because of its rather low water solubility. thumb|center|700px|Acediasulfone synthesis: and (1949, 1952, to Cilag Ltd.); Rawlins, (1952 to [[Parke-Davis).]] In the search for more easily administered drugs, dapsone (1) was reacted with bromoacetic acid to give acediasulfone (2) which can be administered as a water-soluble salt.
== References ==
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).