Structure via PubChem · Public domain (PubChem)
acediasulfone
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Acediasulfone (INN) is an antimicrobial drug, which also has antimalarial activity. It is a long-acting prodrug of dapsone, which is used for treating leprosy. == Synthesis == Dapsone is somewhat inconvenient to administer to patients because of its rather low water solubility. thumb|center|700px|Acediasulfone synthesis: and (1949, 1952, to Cilag Ltd.); Rawlins, (1952 to [[Parke-Davis).]] In the search for more easily administered drugs, dapsone (1) was reacted with bromoacetic acid to give acediasulfone (2) which can be administered as a water-soluble salt.
In the Vinony graph
Vinony's link graph records 117 inbound references to acediasulfone, and connects out to medication, leprosy and digital object identifier.
It sits within the topics 4-Aminophenyl compounds, Abandoned drugs and Benzosulfones.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C14H14N2O4S
- Molecular weight
- 306.34 g/mol
- IUPAC name
- 2-[4-(4-aminophenyl)sulfonylanilino]acetic acid
- SMILES
- C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)NCC(=O)O
- InChIKey
- FKKUMFTYSTZUJG-UHFFFAOYSA-N
- XLogP
- 1
- Polar surface area
- 118 Ų
- H-bond donors
- 3
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 306.067428
Show 2 more facts
- chemical formula
- C₁₄H₁₄N₂O₄S
- canonical SMILES
- C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)NCC(=O)O
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Acediasulfone (INN) is an antimicrobial drug, which also has antimalarial activity. It is a long-acting prodrug of dapsone, which is used for treating leprosy. == Synthesis == Dapsone is somewhat inconvenient to administer to patients because of its rather low water solubility. thumb|center|700px|Acediasulfone synthesis: and (1949, 1952, to Cilag Ltd.); Rawlins, (1952 to [[Parke-Davis).]] In the search for more easily administered drugs, dapsone (1) was reacted with bromoacetic acid to give acediasulfone (2) which can be administered as a water-soluble salt.
== References ==
Excerpted from Wikipedia’s “acediasulfone” article, available under the CC BY-SA 4.0 licence.