Structure via PubChem · Public domain (PubChem)
acepromazine
Sign in to saveAlso known as Acetazine, 10-(3-dimethylaminopropyl)phenothiazine-3-ethylone, 1-[10-(3-DIMETHYLAMINO-propyl)-10H-phenothiazin-2-yl]-ethanone, 10-(3-dimethylaminopropyl)phenothiazin-3-yl methyl ketone, Acetopromazine, Acetylpromazine
Acepromazine, acetopromazine, or acetylpromazine (commonly known as ACP, Ace, or by the trade names Atravet or Acezine 2, number depending on mg/ml dose) is a phenothiazine derivative antipsychotic drug. It was used in humans during the 1950s as an antipsychotic, but is now almost exclusively used on animals as a sedative and antiemetic. A closely related analogue, chlorpromazine, is still used in humans.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 477238349
- Drug.IUPAC_name
- 1-{10-[3-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}ethanone
- Drug.image
- Acepromazine.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Atravet, Acezine 2
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
- Drug.legal_CA
- OTC
- Drug.legal_US
- Rx-only
- Drug.bioavailability
- 6.6 L/kg, high volume of distribution
- Drug.elimination_half life
- 3 hours in horses, 15.9 hours in canines
- Drug.excretion
- urine
- Drug.CAS_number
- 61-00-7
- Drug.ATC_prefix
- N05
- Drug.ATC_suffix
- AA04
- Drug.PubChem
- 6077
- Drug.DrugBank
- DB01614
via Wikipedia infobox
Chemical data
- Formula
- C19H22N2OS
- Molecular weight
- 326.5 g/mol
- IUPAC name
- 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
- SMILES
- CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN(C)C
- InChIKey
- NOSIYYJFMPDDSA-UHFFFAOYSA-N
- XLogP
- 4.2
- Polar surface area
- 48.9 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- psychosis
via ChEMBL · EBI
Research
1,399 papersvia PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 326.145
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₉H₂₂N₂OS
- Commons category
- Acepromazine
- canonical SMILES
- CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN(C)C
- subject has role
- dopamine antagonist
- defined daily dose
- 50
via Wikidata · CC0
~9 min read
Encyclopedic overview
9 sectionsContents
- Pharmacology
- Veterinary use
- Canine and feline
- Adverse effects in cats
- Adverse effects in dogs
- Dogs with a mutation in the ''ABCB1'' (''MDR1'') gene
- Equine
- Adverse effects
- References
{{Infobox drug | Watchedfields = changed | verifiedrevid = 477238349 | IUPAC_name = 1-{10-[3-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}ethanone | image = Acepromazine.svg | image_class = skin-invert-image
| tradename = Atravet, Acezine 2 | Drugs.com = | legal_AU = S4 | legal_BR = C1 | legal_BR_comment = | legal_CA = OTC | legal_US = Rx-only | legal_UK = POM | legal_status = | routes_of_administration = IV, IM, SQ, oral
Excerpted from Wikipedia’s “acepromazine” article, available under the CC BY-SA 4.0 licence.