Structure via PubChem · Public domain (PubChem)
(±)-molindone
Sign in to saveAlso known as (+-)-molindone, EN-1733A, molindone
Molindone, sold under the brand name Moban, is an antipsychotic medication which is used in the United States in the treatment of schizophrenia. It is taken by mouth.
Chemical data
- Formula
- C16H24N2O2
- Molecular weight
- 276.37 g/mol
- IUPAC name
- 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
- SMILES
- CCC1=C(NC2=C1C(=O)C(CC2)CN3CCOCC3)C
- InChIKey
- KLPWJLBORRMFGK-UHFFFAOYSA-N
- XLogP
- 1.7
- Polar surface area
- 45.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1974
- Admin. routes
- oral
- Indications
- psychosis, attention deficit hyperactivity disorder
via ChEMBL · EBI
Research
259 papers- Molindone.2006
- Antipsychotic medication and seizures: a review.Drugs of today (Barcelona, Spain : 1998) · 2003
- Molindone.2012
- Antipsychotic Agents.2012
- Comparative physiological effects of antipsychotic drugs in children and young people: a network meta-analysis.The Lancet. Child & adolescent health · 2024
via PubMed
Wikidata facts
- Subclass of
- medication
- Mass
- 276.183778
Show 8 more facts
- Commons category
- Molindone
- subject has role
- antipsychotics
- chemical formula
- C₁₆H₂₄N₂O₂
- medical condition treated
- schizophrenia
- World Health Organisation international non-proprietary name
- molindone
- canonical SMILES
- CCC1=C(NC2=C1C(=O)C(CC2)CN3CCOCC3)C
- defined daily dose
- 50
- physically interacts with
- Histamine receptor H1
Sources (3)
via Wikidata · CC0
~9 min read
Encyclopedic overview
16 sectionsContents
- Medical uses
- Available forms
- Adverse effects
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Analogues
- Synthesis
- History
- Society and culture
- Availability
- Research
- Depression and anxiety
- Aggression in children and adolescents
- References
Molindone, sold under the brand name Moban, is an antipsychotic medication which is used in the United States in the treatment of schizophrenia. It is taken by mouth.
Side effects of molindone include extrapyramidal symptoms and tardive dyskinesia, among others. Molindone is thought to work by blocking the effects of dopamine in the brain, leading to diminished symptoms of psychosis. The drug is sometimes described as a typical antipsychotic, and sometimes described as an atypical antipsychotic. Chemically, molindone is an indole and is structurally distinct from many other antipsychotics.
Excerpted from Wikipedia’s “(±)-molindone” article, available under the CC BY-SA 4.0 licence.