Structure via PubChem · Public domain (PubChem)
melperone
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Melperone (Bunil (PT), Buronil (AT, BE, CZ, DK, FI†, NL†, NO†, SE), Eunerpan (DE)) is an atypical antipsychotic of the butyrophenone chemical class, making it structurally related to the typical antipsychotic haloperidol. It first entered clinical use in 1960s.
Key facts
- Drug.verifiedrevid
- 447616990
- Drug.IUPAC_name
- 1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one
- Drug.image
- Melperone.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula of melperone
- Drug.width
- 250
- Drug.image2
- Melperone 3D ball.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Space-filling model of the melperone molecule
- Drug.width2
- 250
- Drug.tradename
- Buronil
- Drug.legal_status
- Rx-only
- Drug.routes_of_administration
- Oral, intramuscular injection
- Drug.bioavailability
- 87% (IM), 54% (Oral via syrup), 65% (Oral, tablet)
- Drug.protein_bound
- 50%
- Drug.metabolism
- Hepatic
- Drug.elimination_half life
- 3–4 hours (oral)6 hours (IM)
- Drug.excretion
- Renal (70% as metabolites, 5.5–10.4% as unchanged drug)
via Wikipedia infobox
Chemical data
- Formula
- C16H22FNO
- Molecular weight
- 263.35 g/mol
- IUPAC name
- 1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one
- SMILES
- CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F
- InChIKey
- DKMFBWQBDIGMHM-UHFFFAOYSA-N
- XLogP
- 3.3
- Polar surface area
- 20.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- psychosis, anxiety, Dementia, depressive disorder
via ChEMBL · EBI
Research
193 papers- Interpretation of melperone intoxication: post-mortem concentration distribution and interpretation of intoxication data.Drug metabolism and personalized therapy · 2021
- Zuclopenthixol, melperone and haloperidol/levomepromazine in the elderly. Meta-analysis of two double-blind trials at 15 nursing homes in Norway.Current medical research and opinion · 1992
- Melperone in the treatment of neuroleptic-resistant schizophrenia.Psychiatry research · 2001
- Melperone in the treatment of schizophrenia.Acta psychiatrica Scandinavica. Supplementum · 1989
- Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics.Human psychopharmacology · 2009
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 263.168543
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₆H₂₂FNO
- canonical SMILES
- CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F
- subject has role
- antipsychotics
- medical condition treated
- sleep disorder
- Commons category
- Melperone
via Wikidata · CC0
~4 min read
Encyclopedic overview
8 sectionsContents
- Marketing and indications
- Adverse effects
- Interactions
- Pharmacology
- Synthesis
- See also
- References
- External links
Melperone (Bunil (PT), Buronil (AT, BE, CZ, DK, FI†, NL†, NO†, SE), Eunerpan (DE)) is an atypical antipsychotic of the butyrophenone chemical class, making it structurally related to the typical antipsychotic haloperidol. It first entered clinical use in 1960s.
==Marketing and indications== It has been tried in treatment-resistant cases of schizophrenia with some (albeit limited) success. It has also been reported effective in the treatment of L-DOPA and other forms of psychosis in Parkinson's disease (although a multicentre, double-blind, placebo-controlled study conducted in 2012 failed to support these findings). It is also known to possess anxiolytic properties. It is marketed in the following countries: Austria Czech Republic Denmark Estonia Finland Germany Iceland Lithuania Latvia Portugal Sweden
Excerpted from Wikipedia’s “melperone” article, available under the CC BY-SA 4.0 licence.