ADCYAP1
Sign in to saveAlso known as PACAP, adenylate cyclase activating polypeptide 1
protein-coding gene in the species Homo sapiens
Gene data
ADCYAP1- Name
- adenylate cyclase activating polypeptide 1
- Type
- protein-coding
- Position
- 904,398–912,172 (+)
- Aliases
- PACAP
- Ensembl
- ENSG00000141433
- RefSeq RNA
- NM_001099733.2, NM_001117.5, XM_005258081.5, XM_047437288.1, XM_054318173.1
- RefSeq protein
- NP_001093203.1, NP_001108.2, XP_005258138.2, XP_047293244.1, XP_054174148.1
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013].
Gene Ontology
Biological process
adenylate cyclase-activating G protein-coupled receptor signaling pathwayadenylate cyclase-activating G protein-coupled receptor signaling pathwayadenylate cyclase-activating G protein-coupled receptor signaling pathwayactivation of adenylate cyclase activitypositive regulation of cytosolic calcium ion concentrationneuropeptide signaling pathwayneuropeptide signaling pathwaycell-cell signaling
Molecular function
Pathways
cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Circadian entrainment - Homo sapiens (human)Insulin secretion - Homo sapiens (human)Renin secretion - Homo sapiens (human)Signal TransductionSignal TransductionSignaling by NTRKsActivation of TRKA receptorsNGF-independant TRKA activation
via MyGene.info
Gene · Ensembl
adenylate cyclase activating polypeptide 1
- Symbol
- ADCYAP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 18:904,398-912,172
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ADCYAP1 PDB 2d2p.png
Show 8 more facts
- HomoloGene ID
- 869
- genetic association
- obesity
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/116
- genomic end
- 912173
- genomic start
- 904871
- chromosome
- human chromosome 18
- cytogenetic location
- 18p11.32
Sources (8)
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