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GeneQ18042979· pop 6· linked from 486 articles

ADGRG6

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Also known as APG1, DREG, PS1TP2, VIGR, GPR126, LCCS9, adhesion G protein-coupled receptor G6, PR126

G protein-coupled receptor 126 also known as VIGR and DREG is a protein encoded by the ADGRG6 gene. GPR126 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Gene data

ADGRG6

Name: adhesion G protein-coupled receptor G6
Type: protein-coding
Position: 142,301,502–142,447,264 (+)
Aliases: APG1, DREG, GPR126, LCCS9, PR126, PS1TP2, VIGR
Ensembl: ENSG00000112414
RefSeq RNA: NM_001032394.3, NM_001032395.3, NM_020455.6, NM_198569.3, XM_005267061.4
RefSeq protein: NP_001027566.2, NP_001027567.2, NP_065188.5, NP_940971.2, XP_005267118.1

This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009].

Gene Ontology

Biological process

placenta development cell surface receptor signaling pathway cell surface receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway

Molecular function

endopeptidase activity transmembrane signaling receptor activity G protein-coupled receptor activity G protein-coupled receptor activity G protein-coupled receptor activity G protein-coupled receptor activity G protein-coupled receptor activity G protein-coupled receptor activity

Cellular component

cytoplasm endoplasmic reticulum membrane plasma membrane plasma membrane plasma membrane plasma membrane plasma membrane cell surface

Pathways

Developmental Biology EGR2 and SOX10-mediated initiation of Schwann cell myelination Nervous system development

via MyGene.info

Gene · Ensembl

adhesion G protein-coupled receptor G6

Symbol: ADGRG6
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:142,301,502-142,447,264
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~3 min read

Encyclopedic overview

6 sections

Contents

Ligand
Signaling
Function
Disease
References
External links

G protein-coupled receptor 126 also known as VIGR and DREG is a protein encoded by the ADGRG6 gene. GPR126 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR126 is all widely expressed on stromal cells. The N-terminal fragment of GPR126 contains C1r-C1s, Uegf and Bmp1 (CUB), and PTX-like modules.

Excerpted from Wikipedia’s “ADGRG6” article, available under the CC BY-SA 4.0 licence.

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