ADP-ribosylation
thumb|250px|Adenosine diphosphate ribose|ADP-ribose ADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein. It is a reversible post-translational modification that is involved in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis. Improper ADP-ribosylation has been implicated in some forms of cancer. It is also the basis for the toxicity of bacterial compounds such as cholera toxin, diphtheria toxin, and others.
Research
9,405 papers- ADP-ribosylation from molecular mechanisms to therapeutic implications.Cell · 2023
- ADP-ribosylation of DNA and RNA.DNA repair · 2021
- ADP-ribosylation: An emerging direction for disease treatment.Ageing research reviews · 2024
- ADP-ribosylation signalling and human disease.Open biology · 2019
- PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation.The EMBO journal · 2024
via PubMed
Article
17 sectionsContents
- History
- Catalytic mechanism
- Mono(ADP-ribosyl)ation
- Poly(ADP-ribosyl)ation
- Amino acid specificity
- Function
- Apoptosis
- Gene regulation
- DNA repair
- Protein degradation
- Enzyme regulation
- Clinical significance
- Cancer
- Bacterial toxins
- See also
- References
- Further reading
thumb|250px|Adenosine diphosphate ribose|ADP-ribose ADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein. It is a reversible post-translational modification that is involved in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis. Improper ADP-ribosylation has been implicated in some forms of cancer. It is also the basis for the toxicity of bacterial compounds such as cholera toxin, diphtheria toxin, and others.
==History== The first suggestion of ADP-ribosylation surfaced during the early 1960s. At this time, Pierre Chambon and coworkers observed the incorporation of ATP into hen liver nuclei extract. After extensive studies on the acid insoluble fraction, several different research laboratories were able to identify ADP-ribose, derived from NAD+, as the incorporated group. Several years later, the enzymes responsible for this incorporation were identified and given the name poly(ADP-ribose)polymerase. Originally, this group was thought to be a linear sequence of ADP-ribose units covalently bonded through a ribose glycosidic bond. It was later reported that branching can occur every 20 to 30 ADP residues.