AKT2
Sign in to saveAlso known as v-akt murine thymoma viral oncogene homolog 2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, AKT serine/threonine kinase 2
AKT2, also known as RAC-beta serine/threonine-protein kinase, is an enzyme that in humans is encoded by the AKT2 gene. It influences metabolite storage as part of the insulin signal transduction pathway.
Gene data
AKT2- Name
- AKT serine/threonine kinase 2
- Type
- protein-coding
- Position
- 40,230,317–40,285,536 (−)
- Aliases
- HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA
- Ensembl
- ENSG00000105221
- RefSeq RNA
- NM_001243027.3, NM_001243028.3, NM_001330511.1, NM_001626.6
- RefSeq protein
- NP_001229956.1, NP_001229957.1, NP_001317440.1, NP_001617.1
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- Protein AKT2 PDB 1gzk.png
Show 5 more facts
- HomoloGene ID
- 48773
- exact match
- identifiers.org/ncbigene/208
- genomic end
- 40791443
- genomic start
- 40736224
- cytogenetic location
- 19q13.2
via Wikidata · CC0
~1 min read
Article
6 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
- External links
AKT2, also known as RAC-beta serine/threonine-protein kinase, is an enzyme that in humans is encoded by the AKT2 gene. It influences metabolite storage as part of the insulin signal transduction pathway.
== Function ==