Alfentanil, sold under the brand name Alfenta among others, is a potent, short-acting synthetic opioid analgesic drug used for anesthesia in surgery. It is an analogue of fentanyl with around one-fourth to one-tenth the potency, one-third the duration of action, and an onset of action four times faster than that of fentanyl. Alfentanil has a pKa of approximately 6.5, which leads to a very high proportion of the drug being uncharged at physiologic pH, a characteristic responsible for its rapid-onset. It is an agonist of the μ-opioid receptor.
via PubMed
{{Drugbox | verifiedrevid = 477317188 | class = Opioid | IUPAC_name = N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl}-N-phenylpropanamide | image = Alfentanil-2D-skeletal.svg | image_class = skin-invert-image | width = 220px | caption = Above: Alfentanil structure Below: 3D model of alfentanil molecule | image2 = Alfentanil 3D.png | image_class2 = bg-transparent | width2 = 220px
| tradename = Alfenta, Rapifen, others | Drugs.com = | MedlinePlus = a601130 | legal_AU = S8 | legal_BR = A1 | legal_BR_comment = | legal_CA = Schedule I | legal_UK = Class A | legal_US = Schedule II | legal_DE = Anlage III | routes_of_administration = Intravenous, subcutaneous
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