ALPI
Sign in to saveAlso known as IAP, alkaline phosphatase, intestinal
Alkaline phosphatase, intestinal, also known as ALPI, is a type of alkaline phosphatase that in humans is encoded by the ALPI gene. Its chemical formula is:C2679H4196O965N672S18P2.
Gene data
ALPI- Name
- alkaline phosphatase, intestinal
- Type
- protein-coding
- Position
- 232,456,125–232,460,753 (+)
- Aliases
- IAP
- Ensembl
- ENSG00000163295
- RefSeq RNA
- NM_001631.5
- RefSeq protein
- NP_001622.2
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
alkaline phosphatase, intestinal
- Symbol
- ALPI
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:232,456,125-232,460,753
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Alkaline phosphatase, intestinal, also known as ALPI, is a type of alkaline phosphatase that in humans is encoded by the ALPI gene. Its chemical formula is:C2679H4196O965N672S18P2.
Intestinal alkaline phosphatase is an endogenous enzyme that maintains gut homeostasis. It detoxifyies bacterial toxins, dephosphorylates phosphorylated nucleotides, regulates lipid absorption in the intestine, and regulates the microbiome in the intestine. In addition to these functions, intestinal alkaline phosphatase can also modulate bicarbonate secretion and can modulate the pH of the duodenum.
Excerpted from Wikipedia’s “ALPI” article, available under the CC BY-SA 4.0 licence.