ANAPC2
Sign in to saveAlso known as APC2, anaphase promoting complex subunit 2
Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.
Gene data
ANAPC2- Name
- anaphase promoting complex subunit 2
- Type
- protein-coding
- Aliases
- APC2
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 8359
- exact match
- identifiers.org/ncbigene/29882
- genomic end
- 137188560
- genomic start
- 140069236
- cytogenetic location
- 9q34.3
Sources (4)
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Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.