anidulafungin
Sign in to saveAlso known as Eraxis, V-Echinocandin, (4R,5R)-4,5-Dihydroxy-N²-[[4''-(pentyloxy)-p-terphenyl-4-yl]carbonyl]-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4(p-hydroxyphenyl)-L-threonyl-L-threonyl-(3S,4S)-3-hydroxy-4-methyl-L-proline cyclic (6->1)-peptide, Anidulafungina, Anidulafungine, Anidulafunginum
Anidulafungin (INN) (sold under the brand name Eraxis among others, is a semisynthetic echinocandin used as an antifungal medication. It may also have application in treating invasive Aspergillus infection when used in combination with voriconazole. It is a member of the class of antifungal drugs known as the echinocandins; its mechanism of action is by inhibition of (1→3)-β-D-glucan synthase, an enzyme important to the synthesis of the fungal cell wall.
Research
1,385 papers- Echinocandins Pharmacokinetics: A Comprehensive Review of Micafungin, Caspofungin, Anidulafungin, and Rezafungin Population Pharmacokinetic Models and Dose Optimization in Special Populations.Clinical pharmacokinetics · 2025
- [Anidulafungin].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2008
- Anidulafungin: a novel echinocandin.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2006
- Anidulafungin.Drugs · 2004
- Anidulafungin Vicuron.IDrugs : the investigational drugs journal · 2003
via PubMed
Wikidata facts
- Subclass of
- lipopeptide
- Mass
- 1139.506294
- Has use
- medication
Show 9 more facts
- chemical formula
- C₅₈H₇₃N₇O₁₇
- canonical SMILES
- CCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)NC4CC(C(NC(=O)C5C(C(CN5C(=O)C(NC(=O)C(NC(=O)C6CC(CN6C(=O)C(NC4=O)C(C)O)O)C(C(C7=CC=C(C=C7)O)O)O)C(C)O)C)O)O)O
- isomeric SMILES
- CCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)N[C@H]4C[C@H]([C@H](NC(=O)[C@@H]5[C@H]([C@H](CN5C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H](NC4=O)[C@@H](C)O)O)[C@@H]([C@H](C7=CC=C(C=C7)O)O)O)[C@@H](C)O)C)O)O)O
- subject has role
- antifungal
- World Health Organisation international non-proprietary name
- anidulafungin
- defined daily dose
- 0.1
- medical condition treated
- esophageal candidiasis
- found in taxon
- Streptomyces
- Commons category
- Anidulafungin
via Wikidata · CC0
~5 min read
Encyclopedic overview
8 sectionsContents
- Indications
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Mechanism of action
- Semisynthesis
- History
- References
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 457130635 | IUPAC_name = N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2R)-1,2-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaazatricyclo[22.3.0.09,13]heptacosan-18-yl]- 4-{4-[4-(pentyloxy)phenyl]phenyl}benzamide | image = Anidulafungin structure.svg | image_class = skin-invert-image | width = 300 | alt =
| pronounce = | tradename = Eraxis, others | Drugs.com = | DailyMedID = Anidulafungin | routes_of_administration = Intravenous
Excerpted from Wikipedia’s “anidulafungin” article, available under the CC BY-SA 4.0 licence.