Structure via PubChem · Public domain (PubChem)
ravuconazole
Sign in to saveRavuconazole (codenamed BMS-207147 and ER-30346) is a potent triazole antifungal, the development of which was discontinued in 2007. The drug has shown to have a similar spectrum of activity to voriconazole, with an increased half-life. However, ravuconazole has limited activity against species of Fusarium, Scedosporium, and Zygomycetes.
Chemical data
- Formula
- C22H17F2N5OS
- Molecular weight
- 437.5 g/mol
- IUPAC name
- 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile
- SMILES
- C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=C(C=C4)F)F)O
- InChIKey
- OPAHEYNNJWPQPX-RCDICMHDSA-N
- XLogP
- 3.5
- Polar surface area
- 116 Ų
- H-bond donors
- 1
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- fungal infectious disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 437.112
Show 4 more facts
- chemical formula
- C₂₂H₁₇F₂N₅OS
- canonical SMILES
- CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(CN3C=NC=N3)(C4=C(C=C(C=C4)F)F)O
- isomeric SMILES
- C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=C(C=C4)F)F)O
- Commons category
- Ravuconazole
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- External links
Ravuconazole (codenamed BMS-207147 and ER-30346) is a potent triazole antifungal, the development of which was discontinued in 2007. The drug has shown to have a similar spectrum of activity to voriconazole, with an increased half-life. However, ravuconazole has limited activity against species of Fusarium, Scedosporium, and Zygomycetes.
== See also == Albaconazole Fosravuconazole, a prodrug of ravuconazole Isavuconazole
Excerpted from Wikipedia’s “ravuconazole” article, available under the CC BY-SA 4.0 licence.