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GeneQ18033968· pop 5· linked from 489 articles

TAAR2

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Also known as GPR58, taR-2, trace amine associated receptor 2, trace amine associated receptor 2 (gene/pseudogene)

Trace amine-associated receptor 2 (TAAR2), formerly known as G protein-coupled receptor 58 (GPR58), is a protein that in humans is encoded by the TAAR2 gene. TAAR2 is co-expressed with Gα proteins; however, its signal transduction mechanisms have not been determined.

Gene data

TAAR2
Name
trace amine associated receptor 2
Type
protein-coding
Position
132,617,022–132,624,275 (−)
Aliases
GPR58, taR-2
Ensembl
ENSG00000146378
RefSeq RNA
NM_001033080.1, NM_014626.3
RefSeq protein
NP_001028252.1, NP_055441.2

Predicted to enable trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Pathways

Neuroactive ligand-receptor interaction - Homo sapiens (human)Signal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)Amine ligand-binding receptorsGPCR downstream signallingG alpha (s) signalling eventsGPCR ligand bindingGPCRs, Other

via MyGene.info

Gene · Ensembl

trace amine associated receptor 2

Symbol
TAAR2
Biotype
Protein coding
Organism
Homo sapiens
Location
6:132,617,022-132,624,275
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~3 min read

Encyclopedic overview

7 sections
Contents
  • Tissue distribution
  • Involvement in the functioning of monoamine systems
  • Involvement in adult neurogenesis
  • Involvement in immune cell migration and function
  • Possible Ligands
  • See also
  • References

Trace amine-associated receptor 2 (TAAR2), formerly known as G protein-coupled receptor 58 (GPR58), is a protein that in humans is encoded by the TAAR2 gene. TAAR2 is co-expressed with Gα proteins; however, its signal transduction mechanisms have not been determined.

== Tissue distribution == Human TAAR2 (hTAAR2) is expressed in the cerebellum, olfactory sensory neurons in the olfactory epithelium, and leukocytes (i.e., white blood cells), among other tissues. hTAAR1 and hTAAR2 are both required for white blood cell activation by trace amines in granulocytes.

Excerpted from Wikipedia’s “TAAR2” article, available under the CC BY-SA 4.0 licence.

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