Arrestin beta 1

Also known as ARRB1, non-visual arrestin-2, beta-arrestin-1, Arrestin beta-1, arrestin 2

mammalian protein found in Homo sapiens

In the Vinony graph

Within Vinony's link graph, Arrestin beta 1 is referenced by 85 other articles, and connects out to PubMed, Ensembl genome database project and protein.

It is catalogued under the topic Genes on human chromosome 11.

Its subject is documented across 12 Wikipedia language editions.

Protein · UniProt

Beta-arrestin-1

Gene: ARRB1
Organism: Homo sapiens (Human)
Length: 418 aa
Molecular mass: 47,066 Da
Evidence: 1: Evidence at protein level

Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes (PubMed:37209686, PubMed:38175886, PubMed:40384633). During homologous desensitization, beta-arrestins bind to the GPCR-phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associa…

3D-structureAlternative splicingCell membraneCell projectionCoated pitCytoplasmCytoplasmic vesicleMembrane

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Swiss-Prot (reviewed) · via UniProt