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GeneQ18026347· pop 5· linked from 487 articles

GPR3

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Also known as ACCA, G protein-coupled receptor 3

G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene. The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.

Gene data

GPR3
Name
G protein-coupled receptor 3
Type
protein-coding
Position
27,392,614–27,395,814 (+)
Aliases
ACCA
Ensembl
ENSG00000181773
RefSeq RNA
NM_005281.4
RefSeq protein
NP_005272.1

This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012].

Gene Ontology

Pathways

GPCRs, Class A Rhodopsin-like

via MyGene.info

Gene · Ensembl

G protein-coupled receptor 3

Symbol
GPR3
Biotype
Protein coding
Organism
Homo sapiens
Location
1:27,392,614-27,395,814
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 7 more facts
HomoloGene ID
31303
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/2827
genomic end
27722318
genomic start
27392622
chromosome
human chromosome 1
cytogenetic location
1p36.11
Sources (4)

via Wikidata · CC0

~7 min read

Encyclopedic overview

13 sections
Contents
  • Function
  • Brown adipose tissue Activation
  • Reproductive system
  • Brain cells
  • Ligands
  • Agonists
  • Sphingosine 1-phosphate
  • Diphenyleneiodonium chloride
  • Inverse agonists
  • Cannabidiol
  • Evolution
  • References
  • Further reading

G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene. The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.

GPR3 mRNA is broadly expressed in neurons in various brain regions, including the cortex, thalamus, hypothalamus, amygdala, hippocampus, pituitary, and cerebellum. GPR3 mRNA is also expressed in the eye, lung, kidney, liver, testes, and ovary, among other tissues.

Excerpted from Wikipedia’s “GPR3” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0