GPR3
Sign in to saveAlso known as ACCA, G protein-coupled receptor 3
G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene. The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.
Gene data
GPR3- Name
- G protein-coupled receptor 3
- Type
- protein-coding
- Aliases
- ACCA
This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 31303
- exact match
- identifiers.org/ncbigene/2827
- genomic end
- 27722318
- genomic start
- 27392622
- cytogenetic location
- 1p36.11
Sources (4)
via Wikidata · CC0
~7 min read
Article
13 sectionsContents
- Function
- Brown adipose tissue Activation
- Reproductive system
- Brain cells
- Ligands
- Agonists
- Sphingosine 1-phosphate
- Diphenyleneiodonium chloride
- Inverse agonists
- Cannabidiol
- Evolution
- References
- Further reading
G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene. The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.
GPR3 mRNA is broadly expressed in neurons in various brain regions, including the cortex, thalamus, hypothalamus, amygdala, hippocampus, pituitary, and cerebellum. GPR3 mRNA is also expressed in the eye, lung, kidney, liver, testes, and ovary, among other tissues.