Structure via PubChem · Public domain (PubChem)
benznidazole
Sign in to saveBenznidazole is an antiparasitic medication used in the treatment of Chagas disease. While it is highly effective in early disease, the effectiveness decreases in those who have long-term infection. It is the first-line treatment given its moderate side effects compared to nifurtimox. It is taken by mouth.
Key facts
- Drug.verifiedrevid
- 414638558
- Drug.image
- Benznidazole.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Rochagan, Radanil
- Drug.DailyMedID
- Benznidazole
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- P01
- Drug.ATC_suffix
- CA02
- Drug.legal_US
- Rx-only
- Drug.bioavailability
- High
- Drug.metabolism
- Liver
- Drug.elimination_half life
- 12 hours
- Drug.excretion
- Kidney and fecal
- Drug.CAS_number
- 22994-85-0
- Drug.PubChem
- 31593
- Drug.DrugBank
- DB11989
- Drug.ChemSpiderID
- 29299
- Drug.UNII
- YC42NRJ1ZD
via Wikipedia infobox
Chemical data
- Formula
- C12H12N4O3
- Molecular weight
- 260.25 g/mol
- IUPAC name
- N-benzyl-2-(2-nitroimidazol-1-yl)acetamide
- SMILES
- C1=CC=C(C=C1)CNC(=O)CN2C=CN=C2[N+](=O)[O-]
- InChIKey
- CULUWZNBISUWAS-UHFFFAOYSA-N
- XLogP
- 0.9
- Polar surface area
- 92.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
2,068 papers- Benznidazole.2006
- Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2020
- Use of benznidazole to treat chronic Chagas disease: An updated systematic review with a meta-analysis.PLoS neglected tropical diseases · 2022
- An update on benznidazole for the treatment of patients with Chagas disease.Drugs of today (Barcelona, Spain : 1998) · 2018
- Benznidazole for the treatment of Chagas disease.Expert review of anti-infective therapy · 2021
via PubMed
~8 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Children
- Pregnant women
- Side effects
- Contraindications
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Interactions
- References
Benznidazole is an antiparasitic medication used in the treatment of Chagas disease. While it is highly effective in early disease, the effectiveness decreases in those who have long-term infection. It is the first-line treatment given its moderate side effects compared to nifurtimox. It is taken by mouth.
Side effects are fairly common. They include rash, numbness, fever, muscle pain, loss of appetite, and trouble sleeping. Rare side effects include bone marrow suppression which can lead to low blood cell levels. It is not recommended during pregnancy or in people with severe liver or kidney disease. Benznidazole is in the nitroimidazole family of medication and works by the production of free radicals.
Excerpted from Wikipedia’s “benznidazole” article, available under the CC BY-SA 4.0 licence.