BMPR2
Sign in to saveAlso known as BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK, bone morphogenetic protein receptor type 2
Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase encoded by the BMPR2 gene. It binds bone morphogenetic proteins, members of the TGF beta superfamily of ligands, which are involved in paracrine signaling. BMPs are involved in a host of cellular functions including osteogenesis, cell growth and cell differentiation. Signaling in the BMP pathway begins with the binding of a BMP to the type II receptor. This causes the recruitment of a BMP type I receptor, which the type II receptor phosphorylates. The type I receptor phosphorylates an R-SMAD, a transcrip
Gene data
BMPR2- Name
- bone morphogenetic protein receptor type 2
- Type
- protein-coding
- Position
- 202,375,835–202,567,751 (+)
- Aliases
- BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK
- Ensembl
- ENSG00000204217
- RefSeq RNA
- NM_001204.7, NM_001445553.1, NM_001445554.1, NM_001445555.1, NM_001445556.1
- RefSeq protein
- NP_001195.2, NP_001432482.1, NP_001432483.1, NP_001432484.1, NP_001432485.1
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, May 2020].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
bone morphogenetic protein receptor type 2
- Symbol
- BMPR2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:202,375,835-202,567,751
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 929
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/659
- genomic end
- 203432474
- genomic start
- 202376327
- chromosome
- human chromosome 2
- cytogenetic location
- 2q33.1-q33.2
- Commons category
- BMPR2
via Wikidata · CC0
Article · Русский
BMPR2 (рецептор костного морфогенетического белка II типа) — рецептор с серин/треонинкиназной ативностью. Он связывает BMP (костные морфогенетические белки) бета-субъединиц , вовлеченных в , что является формой коммуникации клеток, в которой клетка передает сигнал, вызывающий изменения в соседних клетках, изменяя их поведение или дифференцировку. Передача сигналов в BMP-пути начинается с присоединения BMP к рецептору II типа. Это вызывает вовлечение BMP рецептора I типа, который подвергается фосфорелированию. Фосфорилат рецептора I типа — R-SMAD транскрипционный регулятор. Функции BMPs: * участие в остеогенезе * в росте клеток * в дифференцировке клеток
Abstract from DBpedia / Wikipedia · CC BY-SA
Available in 6 languages
via Wikidata sitelinks · CC0