Structure via PubChem · Public domain (PubChem)
bremazocine
Sign in to saveBremazocine is a κ-opioid receptor agonist related to pentazocine. It has potent and long-lasting analgesic and diuretic effects. It has 200 times the activity of morphine, but appears to have no addictive properties and does not depress breathing. The crystal structure of bremazocine was determined in 1984
Chemical data
- Formula
- C20H29NO2
- Molecular weight
- 315.4 g/mol
- IUPAC name
- 1-ethyl-10-[(1-hydroxycyclopropyl)methyl]-13,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol
- SMILES
- CCC12CCN(C(C1(C)C)CC3=C2C=C(C=C3)O)CC4(CC4)O
- InChIKey
- ZDXGFIXMPOUDFF-UHFFFAOYSA-N
- XLogP
- 3.9
- Polar surface area
- 43.7 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
533 papers- Bremazocine: a kappa-opioid agonist with potent analgesic and other pharmacologic properties.CNS drug reviews · 2005
- Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.Proceedings of the National Academy of Sciences of the United States of America · 1988
- Bremazocine: a potent, long-acting opiate kappa-agonist.Life sciences · 1980
- Multiple opioid receptors.Medicinal research reviews · 1981
- Bremazocine: an opiate that induces sedation and analgesia without respiratory depression.Anesthesia and analgesia · 1983
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 315.219829
Show 3 more facts
- chemical formula
- C₂₀H₂₉NO₂
- canonical SMILES
- CCC12CCN(C(C1(C)C)CC3=C2C=C(C=C3)O)CC4(CC4)O
- subject has role
- analgesic
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Bremazocine is a κ-opioid receptor agonist related to pentazocine. It has potent and long-lasting analgesic and diuretic effects. It has 200 times the activity of morphine, but appears to have no addictive properties and does not depress breathing. The crystal structure of bremazocine was determined in 1984
== See also == Benzomorphan
Excerpted from Wikipedia’s “bremazocine” article, available under the CC BY-SA 4.0 licence.