CACNA2D3

Also known as HSA272268, calcium voltage-gated channel auxiliary subunit alpha2delta 3

Calcium channel, voltage-dependent, alpha 2/delta subunit 3 is a protein that in humans is encoded by the CACNA2D3 gene on chromosome 3 (locus 3p21.1).

In the Vinony graph

Within Vinony's link graph, CACNA2D3 is referenced by 4 other articles, and connects out to PubMed, stomach cancer and human chromosome 3.

It is catalogued under topics including Genes on human chromosome 3 and Ion channels.

Its subject is documented across 5 Wikipedia language editions.

Gene data

CACNA2D3

Name: calcium voltage-gated channel auxiliary subunit alpha2delta 3
Type: protein-coding
Position: 54,122,127–55,074,557 (+)
Aliases: HSA272268
Ensembl: ENSG00000157445
RefSeq RNA: NM_018398.3
RefSeq protein: NP_060868.2

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

calcium ion transport positive regulation of muscle contraction calcium ion transmembrane transport calcium ion transmembrane transport regulation of presynapse organization cellular response to insulin-like growth factor stimulus

Molecular function

voltage-gated calcium channel activity voltage-gated calcium channel activity

Cellular component

voltage-gated calcium channel complex membrane T-tubule presynaptic active zone membrane GABA-ergic synapse L-type voltage-gated calcium channel complex

Pathways

MAPK signaling pathway - Homo sapiens (human)Cardiac muscle contraction - Homo sapiens (human)Adrenergic signaling in cardiomyocytes - Homo sapiens (human)Oxytocin signaling pathway - Homo sapiens (human)Hypertrophic cardiomyopathy - Homo sapiens (human)Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)Dilated cardiomyopathy - Homo sapiens (human)Presynaptic depolarization and calcium channel opening Transmission across Chemical Synapses Neuronal System

via MyGene.info

Gene · Ensembl

calcium voltage-gated channel auxiliary subunit alpha2delta 3

Symbol: CACNA2D3
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:54,122,127-55,074,557
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 9 more facts

HomoloGene ID: 74929
genetic association: smallpox
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/55799
chromosome: human chromosome 3
genomic start: 54156574
genomic end: 55108584
cytogenetic location: 3p21.1-p14.3
expressed in: prefrontal cortex

Sources (5)

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Encyclopedic overview

7 sections

Contents

Function
Clinical significance
Breast cancer
Gastric cancer
References
External links
Further reading

Calcium channel, voltage-dependent, alpha 2/delta subunit 3 is a protein that in humans is encoded by the CACNA2D3 gene on chromosome 3 (locus 3p21.1).

== Function ==

Excerpted from Wikipedia’s “CACNA2D3” article, available under the CC BY-SA 4.0 licence.