CACNA1D
Sign in to saveAlso known as CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, PASNA, SANDD, calcium voltage-gated channel subunit alpha1 D
Calcium channel, voltage-dependent, L type, alpha 1D subunit (also known as Cav1.3) is a protein that in humans is encoded by the CACNA1D gene. Cav1.3 channels belong to the Cav1 family, which form L-type calcium currents and are sensitive to selective inhibition by dihydropyridines (DHP).
Gene data
CACNA1D- Name
- calcium voltage-gated channel subunit alpha1 D
- Type
- protein-coding
- Aliases
- CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, PASNA, SANDD
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012].
via MyGene.info
Wikidata facts
- Image
- Protein CACNA1D PDB 2be6.png
Show 5 more facts
- HomoloGene ID
- 578
- exact match
- identifiers.org/ncbigene/776
- genomic end
- 53847760
- genomic start
- 53528683
- cytogenetic location
- 3p21.1
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~9 min read
Article
14 sectionsContents
- Structure and function
- Regulation
- Alternative splicing
- Negative feedback
- Clinical significance
- Hearing
- Chromaffin cells
- Neurodegeneration
- Prostate cancer
- Aldosteronism
- See also
- References
- Further reading
- External links
Calcium channel, voltage-dependent, L type, alpha 1D subunit (also known as Cav1.3) is a protein that in humans is encoded by the CACNA1D gene. Cav1.3 channels belong to the Cav1 family, which form L-type calcium currents and are sensitive to selective inhibition by dihydropyridines (DHP).
==Structure and function== 200 px|thumb|left|Schematic representation of the alpha subunit of VDCCs showing the four homologous domains, each with six transmembrane subunits. P-loops are highlighted red, S4 subunits are marked with a plus indicative of positive charge. Voltage-dependent calcium channels (VDCC) are selectively permeable to calcium ions, mediating the movement of these ions in and out of excitable cells. At resting potential, these channels are closed, but when the membrane potential is depolarised these channels open. The influx of calcium ions into the cell can initiate a myriad of calcium-dependent processes including muscle contraction, gene expression, and secretion. Calcium-dependent processes can be halted by lowering intracellular calcium levels, which, for example, can be accomplished by calcium pumps.