कॉल्मोड्यूलिन
Also known as CaM, Calmodulin, IPR039030, calmodulin
thumb|The helix–loop–helix structure of the calcium-binding EF hand motif Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+ is required for the activation of calmodulin. Once bound to Ca2+, calmodulin acts as part of a calcium signal transduction pathway by modifying its interactions with various target proteins such as kinases or phosphatases.
Key facts
- Protein.name
- Calmodulin
- Protein.image
- Calmodulin.png
- Protein.caption
- 3D structure of Ca2+-bound calmodulin ()
- Protein.Symbol
- CaM
- Protein.PDB
- 1OSA
- Protein.UniProt
- P62158
via Wikipedia infobox
Research
4,434 papers- Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane-targeting motifs.Proceedings of the National Academy of Sciences of the United States of America · 2021
- Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry.European heart journal · 2023
- The calmodulin multigene family as a unique case of genetic redundancy: multiple levels of regulation to provide spatial and temporal control of calmodulin pools?