cAMP response element binding protein
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alt=|thumb|200x200px|CREB (top) is a transcription factor capable of binding [[DNA (bottom) and regulating gene expression.]] CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene.
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9 sectionsContents
- Subtypes
- Structure
- Mechanism of action
- Function in the brain
- Disease linkage
- Involvement in circadian rhythms
- Discovery of CREB involvement in circadian rhythms
- References
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alt=|thumb|200x200px|CREB (top) is a transcription factor capable of binding [[DNA (bottom) and regulating gene expression.]] CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene.
Genes whose transcription is regulated by CREB include: c-fos, BDNF, tyrosine hydroxylase, numerous neuropeptides (such as somatostatin, enkephalin, VGF, corticotropin-releasing hormone), and genes involved in the mammalian circadian clock (PER1, PER2).