ATF1
Sign in to saveAlso known as EWS-ATF1, FUS/ATF-1, TREB36, activating transcription factor 1
Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.
Gene data
ATF1- Name
- activating transcription factor 1
- Type
- protein-coding
- Position
- 50,763,710–50,821,162 (+)
- Aliases
- EWS-ATF1, FUS/ATF-1, TREB36
- Ensembl
- ENSG00000123268
- RefSeq RNA
- NM_001412960.1, NM_001412961.1, NM_001412962.1, NM_001412963.1, NM_001412964.1
- RefSeq protein
- NP_001399889.1, NP_001399890.1, NP_001399891.1, NP_001399892.1, NP_001399893.1
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 3790
- exact match
- identifiers.org/ncbigene/466
- genomic end
- 50821162
- genomic start
- 51157493
- cytogenetic location
- 12q13.12
Sources (3)
via Wikidata · CC0
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Article
6 sectionsContents
- Clinical significance
- See also
- Interactions
- References
- Further reading
- External links
Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.