Caspase 5
Sign in to saveAlso known as protease ICH-3, CASP5, caspase-5, CASP-5, TY protease, caspase 5, apoptosis-related cysteine peptidase, ICE(rel)-III, protease TY
mammalian protein found in Homo sapiens
Protein · UniProt
Caspase-5
- Gene
- CASP5
- Organism
- Homo sapiens (Human)
- Length
- 434 aa
- Molecular mass
- 49,736 Da
- Evidence
- 1: Evidence at protein level
Thiol protease that acts as a mediator of programmed cell death (PubMed:28314590, PubMed:29898893). Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis (PubMed:29898893). Also mediates cleavage and maturation of IL18 (PubMed:37993714). Cleavage of GSDMD and IL18 is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 (PubMed:37993714). During non-canonical infl…
Swiss-Prot (reviewed) · via UniProt