catechol-O-methyltransferase
thumb|350px|Norepinephrine degradation. Catechol-O-methyltransferase is shown in green boxes. 'Catechol-O-methyltransferase (COMT'; ) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical c
Key facts
- Enzyme.Name
- catechol-O-methyltransferase
- Enzyme.EC_number
- 2.1.1.6
- Enzyme.CAS_number
- 9012-25-3
- Enzyme.GO_code
- 0016206
via Wikipedia infobox
Research
6,657 papers- Catechol-O-methyltransferase, Cognition and Alzheimer's Disease.Current Alzheimer research · 2018
- Catechol-O-methyltransferase, dopamine, and sleep-wake regulation.Sleep medicine reviews · 2015
- Catechol-O-methyltransferase gene Val158Met polymorphism and obsessive compulsive disorder susceptibility: a meta-analysis.Metabolic brain disease · 2020
- Catechol-O-methyltransferase 158G/A polymorphism and endometriosis/adenomyosis susceptibility: A meta-analysis in the Chinese population.Journal of cancer research and therapeutics · 2018
Article
11 sectionsContents
- Function
- Genetics in humans
- Val<sup>158</sup>Met polymorphism
- Temporomandibular joint dysfunction
- Nomenclature
- COMT inhibitors
- See also
- Additional images
- References
- Further reading
- External links
thumb|350px|Norepinephrine degradation. Catechol-O-methyltransferase is shown in green boxes. 'Catechol-O-methyltransferase (COMT'; ) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines. COMT was first discovered by the biochemist Julius Axelrod in 1957.
== Function == Catechol-O-methyltransferase is involved in the inactivation of the catecholamine neurotransmitters (dopamine, epinephrine, and norepinephrine). The enzyme introduces a methyl group to the catecholamine, which is donated by S-adenosyl methionine (SAM). Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT.